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目的探讨IL-1BT-31C和C-511T基因多态性与宫颈高危人乳头瘤病毒(HPV)持续感染遗传易感性的关系。方法采用聚合酶链式反应和限制性片段长度多态性(PCR-RFLP)检测中国江苏部分地区高危HPV持续感染(A组,223例)和感染自我清除的汉族女性(B组,186例)IL-1B T-31C、C-511T基因型分布。结果两组IL-1BT-31C和C-511T位点各基因型分布无统计学差异(P>0.05)。IL-1BT-31C和C-511T位点的基因频率与HPV持续感染遗传易感性均无明显相关性(P>0.05)。结论在中国江苏汉族女性人群中,IL-1B T-31C和C-511T基因多态性可能与高危HPV持续感染遗传易感性无关。
Objective To investigate the relationship between genetic polymorphisms of IL-1BT-31C and C-511T and the genetic susceptibility to persistent infection with high-risk human papillomavirus (HPV) in the cervix. Methods Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to detect persistent high-risk HPV infection in part of Jiangsu province (group A, n = 223) and self-clearing Han women IL-1B T-31C, C-511T genotype distribution. Results There was no significant difference in genotype distribution between IL-1BT-31C and C-511T loci (P> 0.05). There were no significant correlations between the gene frequencies of IL-1BT-31C and C-511T loci and the susceptibility to persistent HPV infection (P> 0.05). Conclusion The polymorphisms of IL-1B T-31C and C-511T in Chinese Han women of Jiangsu province may not be related to the genetic predisposition of persistent high-risk HPV infection.