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目的探讨血清癌胚抗原(CEA)和组织多肽特异性抗原(TPS)联合检测对胃癌诊断的价值。方法送检胃癌患者60例,胃良性肿瘤30例,正常对照组30例患者静脉血标本,应用酶联免疫吸附试验法(ELISA)检测TPS,应用电化学发光法检测CEA血清含量。结果胃癌组2项指标均明显高于胃良性肿瘤组和正常对照组(P<0.01),两项标志物联合检测的敏感性比单项检测明显增高。结论 CEA和TPS对胃癌诊断有一定价值,两者联合检测可以明显提高胃癌患者诊断的敏感性。
Objective To investigate the diagnostic value of serum carcinoembryonic antigen (CEA) and tissue polypeptide specific antigen (TPS) in the diagnosis of gastric cancer. Methods Totally 60 gastric cancer patients, 30 benign gastric tumors and 30 normal control subjects were enrolled in this study. TPS was detected by enzyme-linked immunosorbent assay (ELISA) and CEA serum was detected by electrochemiluminescence. Results Two indexes in gastric cancer group were significantly higher than those in gastric benign tumor group and normal control group (P <0.01). The sensitivity of combined detection of two markers was significantly higher than that of single detection. Conclusions CEA and TPS have some value in the diagnosis of gastric cancer. The combined detection of CEA and TPS can significantly improve the diagnostic sensitivity of gastric cancer patients.