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目的:分析注射用母牛分枝杆菌辅助治疗肺结核的临床效果,为临床工作者提供参考。方法:回顾分析自2013年1月-2014年12月期间河源市龙川县慢性病防治院收治的100例肺结核患者的临床资料。将100例患者随机分为观察组和对照组,每组50例。给予观察组患者化疗联合注射用母牛分枝杆菌,给予对照组患者单纯性化疗。两组患者的化疗方案相同(初治2HRZE/4HR;复治2HRZES/6HRE),观察比较两组患者的痰菌阴转、病灶吸收及空洞闭合情况。结果:观察组的痰菌阴转率为94.00%;对照组痰菌阴转率为82.00%,差异具有统计学意义(P<0.05);观察组的病灶吸收及空洞闭合情况均高于对照组,差异具有统计学意义(P<0.05)。结论:注射用母牛分枝杆菌辅助治疗肺结核疗效显著,尤其是治疗复治结核病。
Objective: To analyze the clinical effect of adjuvant treatment with Mycobacterium vaccae in the treatment of pulmonary tuberculosis and provide a reference for clinicians. Methods: The clinical data of 100 cases of tuberculosis admitted to Longchuan County Chronic Prevention and Treatment Hospital of Heyuan City from January 2013 to December 2014 were retrospectively analyzed. 100 patients were randomly divided into observation group and control group, 50 cases in each group. Patients in the observation group were given chemotherapy combined with Mycobacterium vaccae and patients in the control group were given chemotherapy alone. The two groups of patients with the same chemotherapy (initial treatment 2HRZE / 4HR; retreatment 2HRZES / 6HRE), two groups of patients were observed sputum negative conversion, focal absorption and empty closure. Results: The negative conversion rate of sputum in the observation group was 94.00%; the negative conversion rate of sputum in the control group was 82.00%, the difference was statistically significant (P <0.05); the absorption of the lesion and the cavity closed in the observation group were higher than those in the control group , The difference was statistically significant (P <0.05). Conclusion: Mycobacterium vaccae injection has a significant effect in adjuvant treatment of pulmonary tuberculosis, especially in the treatment of retreatment tuberculosis.