由于疟原虫的耐药以及有效药物对胎儿的潜在毒性,所以孕妇恶性疟是难治的。作者报道一种能消除疟原虫感染而对孕妇和胎儿又无毒性作用的新药——甲氟喹,治愈一例孕妇恶性疟患者。病例资料患者24岁,女性,妊娠33周。发热、腹泻、呕吐和背痛3天,曾患过疟疾和伤寒。体查:体温升高,巩膜黄染、脾大柔软。血红蛋白105g/L,薄血片找到含有3%密度的恶性疟原虫小滋养体。开始静注补液,口服甲氟喹750mg(3片),服后呕吐,随即给服灭吐灵,首次2片,仍继续呕吐,改用静注双倍剂量灭吐灵后,并服甲氟喹250mg,不 Plasmodium falciparum in pregnant women is refractory due to the resistance of Plasmodium and the potential toxicity of effective drugs to the fetus. The authors report that mefloquine, a new drug that eliminates Plasmodium infection and is non-toxic to pregnant women and fetuses, has cured one case of malaria in pregnant women. Case information Patients 24 years old, female, 33 weeks of gestation. Fever, diarrhea, vomiting and back pain for 3 days, have had malaria and typhoid fever. Physical examination: body temperature, scleral yellow dye, splenomegaly soft. Hemoglobin 105g / L, thin blood film to find contains 3% density of Plasmodium falciparum nauplii. Start intravenous rehydration, oral mefloquine 750mg (3 tablets), vomiting after serving, and then to the service off to spit, the first two tablets, continue to vomit, switch to intravenous double dose metoclopramide, Quinole 250 mg, no