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以2-溴-4′-氟苯乙酮及硫脲为原料,经取代、缩合和酰化后,再与N-杂环化合物反应,合成得到5个N-杂环取代氨基噻唑衍生物,其结构经1H NMR和13C NMR表征。
Using 2-bromo-4’-fluoroacetophenone and thiourea as raw materials, 5 N-heterocyclic substituted aminothiazole derivatives were synthesized through the reaction of substitution, condensation and acylation followed by reaction with N-heterocyclic compounds. Its structure was characterized by 1H NMR and 13C NMR.