脑动脉瘤是神经外科常见疾病,其破裂出血后的死亡率较高,通过建立脑动脉瘤的动物模型可以更好地了解动脉瘤的发生、发展,对动脉瘤的诊断和治疗提供重要帮助。脑动脉瘤动物模型制备的方法很多,主要包括外科手术法、介入制作法、血流动力学诱导法、药物诱导法及胰蛋白酶注射法等,本文着重介绍这些方法。 Cerebral aneurysm is a common disease in neurosurgery, and its mortality after rupture of hemorrhage is high. Animal models of cerebral aneurysm can be used to better understand the occurrence and development of aneurysm and provide important help for the diagnosis and treatment of aneurysm. Animal models of cerebral aneurysms are many methods of preparation, including surgical methods, interventional production method, hemodynamic induction, drug induction and trypsin injection, etc., this article focuses on these methods.