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目的:基于数据挖掘清代佚人所撰《毓麟验方》中医药治疗男女不育不孕病用药配伍思路的文献研究。方法:将清代佚人所撰《毓麟验方》治疗男女不育不孕病的中医复方方药录入计算机,建立数据库,运用统计学方法分析其用药配伍规律。结果:整理中药复方117首中药内服复方,涉及199味中药,用药总次数964次;高频次核心药以麝香、丁香、附子、肉桂、蛇床子、川椒、蟾酥、淫羊藿等为主;药类以补虚药、温里药、开窍药、收涩药等为主;药味以辛、甘、苦为主,累计频率达80.68%;药性以温、平、寒为主,累计频率达87.87%;归经以肾、脾、肝、心、肺、胃为主,累计频率91.39%。结论:该古籍临证选用高频次麝香、丁香、附子、肉桂、蛇床子、川椒、蟾酥、淫羊藿加减处方用药;突显以温里药和补阳药相参加减治疗男女不育不孕证的用药特点。
OBJECTIVE: To study the literature of “Yulin prescription” compatibility of traditional Chinese medicine in the treatment of male and female infertility infertility based on data mining. Methods: The prescriptions of “Yulin prescription”, a traditional Chinese medicine prescription for the treatment of infertility infertility of men and women, were collected into the computer, and the database was established. The statistical analysis was used to analyze the compatibility of the prescriptions. Results: 117 Chinese herbal compound prescriptions were collected, involving 199 herbs, the total number of medication 964 times; high-frequency core drugs to musk, clove, aconite, cinnamon, Cnidium, Chuan Jiao, toad, Epimedium ; Medicine to tonic medicine, temperature medicine, resuscitation medicine, medicine astringent; mainly in syrup, sweet, bitter, the cumulative frequency of 80.68%; drug to warm, flat, cold-based, the cumulative frequency Up to 87.87%; returned to the kidney, spleen, liver, heart, lung, stomach-based, the cumulative frequency of 91.39%. Conclusion: The ancient books clinical application of high-frequency musk, clove, aconite, cinnamon, Cnidium, Chuanjiao, toad, epimedium prescription medication; highlight the temperature in medicine and yang medicine phase reduction treatment of male and female infertility Infertility card drug characteristics.