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目的:对儿童药物不良反应(ADR)的基本情况和发生特点进行分析总结。方法:对2009年至2011年我院上报给国家药品不良反应监测网的351例ADR报告进行回顾性统计分析。结果:男222例,女129例;1～3岁幼儿发生ADR的比例最高(38.50%);静脉滴注引起的ADR比例最高(79.45%);皮肤及附件损害为最主要的ADR,占75.50%;抗生素和中药注射剂引起的ADR占较高比例。结论:应加强儿科不良反应监测工作,保障患儿安全用药。
Objective: To analyze and summarize the basic situation and occurrence characteristics of children’s adverse drug reaction (ADR). Methods: A retrospective statistical analysis was performed on 351 ADR cases reported by our hospital from 2009 to 2011 to the national ADR monitoring network. Results: There were 222 males and 129 females. The highest incidence of ADR occurred in children aged 1-3 years (38.50%), the highest proportion of ADR (79.45%) caused by intravenous drip and the most important ADR in skin and accessory lesions (75.50%) %; ADR caused by antibiotics and Chinese medicine injection accounted for a higher proportion. Conclusion: Adverse reaction monitoring should be strengthened in pediatric patients to ensure the safety of children.