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中性粒细胞抗原NA1和NA2是FCPⅢB受体上两个已确认的等位基因编码。FCRⅢB是一种低亲和力受体,常以免疫复合物的形式存在于血循环中。系统性红斑狼疮(SLE)是一种自身免疫性疾病,以免疫复合物堆积导致多系统失调为特征。作者所在的医疗中心多数的SLE患者是华人,其次是马来人和印度人。近来,对不同民族该受体频率及其与SLE相关性研究成为焦点。作者选择居住在马来西亚的马来人和华人,采用聚合酶链-等位基因特异性引物(PCRASP)方法区别两种等位基因。分型用DNA来自受检者外周血,其中183例华人SLE患者,55例马来人SLE患者,100例健康华人,50例健康马来人。检则结
Neutrophil antigens NA1 and NA2 are two of the identified alleles on the FCPIIIB receptor. FCRIIIB is a low-affinity receptor, often in the form of immune complexes in the bloodstream. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by accumulation of immune complexes leading to multiple systemic disorders. The majority of SLE patients at the author’s medical center were Chinese, followed by Malay and Indians. Recently, research has focused on the frequency of this receptor from different ethnic groups and their association with SLE. The authors chose Malay and Chinese living in Malaysia and used polymerase chain-allele-specific primers (PCRASP) to distinguish between the two alleles. The genotyping DNA was obtained from peripheral blood of subjects, including 183 Chinese SLE patients, 55 Malay SLE patients, 100 healthy Chinese, and 50 healthy Malays. Check the knot