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目的探讨鸡皮样胃炎采用含左氧氟沙星三联疗法治疗的临床效果。方法 100例鸡皮样胃炎患者随机分为观察组和对照组,各50例。观察组采用含左氧氟沙星三联疗法,对照组采用含克拉霉素的经典三联疗法,对比两组患者临床疗效。结果观察组幽门螺杆菌(Hp)根除率为88%,略高于对照组的82%,但差异无统计学意义(P>0.05)。观察组恶心2例,不良反应率为4%,对照组皮疹1例,腹痛2例,不良反应率为6%,两组比较差异无统计学意义(P>0.05)。结论针对鸡皮样胃炎患者,采用含左氧氟沙星的三联疗法根除Hp效果显著,且具较高安全性,可作为一线治疗方案,以改善预后,最大程度保障患者生存质量。
Objective To investigate the clinical effect of triple therapy with levofloxacin in chicken skin-like gastritis. Methods 100 cases of chicken dermatitis gastritis were randomly divided into observation group and control group, 50 cases each. The observation group was treated with levofloxacin triple therapy, while the control group was treated with classic triple therapy with clarithromycin to compare the clinical efficacy of the two groups. Results The eradication rate of Helicobacter pylori (Hp) in the observation group was 88%, slightly higher than that in the control group (82%), but the difference was not statistically significant (P> 0.05). In the observation group, nausea occurred in 2 cases and adverse reaction rate was 4%. In the control group, 1 case had a rash and 2 cases had abdominal pain. The adverse reaction rate was 6%. There was no significant difference between the two groups (P> 0.05). Conclusions For the patients with chicken skin gastritis, the triple therapy with levofloxacin can effectively eradicate Hp and has high safety. It can be used as first-line treatment to improve the prognosis and maximize the quality of life of patients.