由于许多病原菌对抗生素耐药以及一些抗生素不易透入蜘蛛膜下腔,因而使需氧革兰氏阴性杆菌脑膜炎的有效治疗受到限制。由于感染的脑脊液缺少补体和调理素活性,使宿主对各种荚膜菌所致化脓性脑膜炎的免疫反应也受到损害,因此,治疗本病宜首选杀菌抗生素。氯霉素很容易透入脑脊液,但对肠道革兰氏阴性杆菌来说,属于抑菌抗生素。氨基糖甙族虽系杀菌抗生素,但必须每日腰椎内或脑室内注射。新的头孢菌素化合物——羟羟氧头孢菌素(Moxalactam)和氨噻肟头孢菌素(Cefotaxime)在很低浓度下 Because many pathogens are resistant to antibiotics and some antibiotics do not readily penetrate into the subarachnoid space, effective treatment of aerobic gram-negative bacilli meningitis is limited. Due to the lack of complement and opsonic activity in the infected cerebrospinal fluid, the host immune response to purulent meningitis caused by various capsular bacteria is also impaired. Therefore, the treatment of this disease is the preferred bactericidal antibiotics. Chloramphenicol is very easy to penetrate the cerebrospinal fluid, but intestinal gram-negative bacilli, antibacterial antibiotics. Although aminoglycoside antibacterial family bactericides, but must be daily intra-lumbar or intraventricular injection. The new cephalosporin compounds - Moxalactam and cefotaxime (Cefotaxime) at very low concentrations