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目的 探讨暴发型流行性脑脊髓膜炎 (流脑 ,FMM )患者并发的心肌损伤。方法 1 6例生前有心功能不全病史的暴发型流脑患者 ,分别在入院时及出现临床心力衰竭或中枢神经系统症状时抽血测定血清肌钙蛋白I(cTnI)浓度 ,部分病例死亡后立即穿刺心室肌 ,制成超薄切片后电镜观察超微结构改变。结果 1 6例患者临床症状明显时血清cTnI浓度均明显增高 (P <0 0 0 1 ) ,电镜示有心肌细胞变性坏死及肌丝破坏。结论 暴发型流脑常并发心肌损伤 ,cTnI是诊断的可靠依据
Objective To investigate the myocardial injury complicated by fulminant cerebrospinal meningitis (meningitis, meningitis, FMM). Methods Sixteen patients with fulminant meningitis who had a history of heart failure before admission were enrolled in the study. Blood concentrations of serum cardiac troponin I (cTnI) were measured at admission and in patients with clinical heart failure or central nervous system symptoms. Some cases were punctured immediately after they died Ventricular muscle, made of ultra-thin sections after electron microscopy ultrastructural changes. Results Serum levels of cTnI were significantly increased in 16 patients with clinical symptoms (P <0.01). Electron microscopy showed myocardial cell degeneration and necrosis and myofilament destruction. Conclusions Fulminant mesolimbic often complicated with myocardial injury, cTnI is a reliable basis for diagnosis