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目的:探讨高氟环境对骨代谢及钙、镁元素的影响。方法:对1 060名12~15岁的中学生(调查组为高氟病区吉林省通榆县520例,对照组为吉林省德惠县540例)氟斑牙的患病情况进行了调查,并对血中氟(F)、钙(Ca)、镁(Mg)元素及碱性磷酸酶(ALP)的水平进行了检测,采用统计学方法对所得数据进行统计学分析。结果:高氟地区中学生氟斑牙患病率(73.1%)明显高于对照组(7.5%)。高氟地区学生血清氟元素水平高于对照组,差异具有统计学意义(P<0.01);而血清Ca、Mg元素的水平调查组均低于对照组,差异有统计学意义(P<0.05);血清ALP水平调查组高于对照组但差异无统计学意义(P>0.05)。结论:高氟环境会显著增加氟斑牙的患病率,同时会导致机体钙、镁元素水平的降低,从而影响了骨的代谢过程。因此,应加强在地氟病流行区采取综合性的措施,减少环境中的氟元素,从而降低高氟对人体所造成的影响。
Objective: To explore the effect of high fluoride environment on bone metabolism and calcium and magnesium. Methods: The prevalence of dental fluorosis in 1,060 secondary school students aged 12-15 years (survey group: 520 in Tongyu County, Jilin Province with high fluoride disease and 540 in Dehui County, Jilin Province) The blood levels of fluoride, calcium, magnesium and alkaline phosphatase (ALP) were measured. The data were statistically analyzed by statistical methods. Results: The prevalence of dental fluorosis in high school students (73.1%) was significantly higher than that in the control group (7.5%). The levels of serum fluoride in high-fluoride students were significantly higher than those in the control group (P <0.01), while the levels of Ca and Mg in serum were lower than those in the control group (P0.05) The serum ALP level in the survey group was higher than that in the control group, but the difference was not statistically significant (P> 0.05). Conclusion: High fluoride environment will significantly increase the prevalence of dental fluorosis, and will lead to the reduction of calcium and magnesium levels in the body, thus affecting the bone metabolism. Therefore, we should step up comprehensive measures to reduce the fluoride content in the environment in endemic areas with endemic Fluorosis so as to reduce the impact of high fluoride on the human body.