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作者对小太郎中药制药株式公司炮附子末的毒性采用小白鼠及大白鼠进行实验研究。其结果认为,经口投药时毒性弱,且在可能的给予量中未求得半致死量。经口投药时,小白鼠、大白鼠一般中毒症状相同,即由服药后30分钟左右开始镇静,随意运动抑制,呼吸初开始是加快,以后转入抑制,死亡者可见跳跃转倒,引起搐搦样痉挛者少见,多因呼吸麻痹而窒息。腹腔注射时的半致死量如下表示,两种鼠均稳定在14.2—17.0g/kg范围。雌雄之间无显著差异。
The authors studied the toxicity of Xiao Tailang Traditional Chinese Medicine Co., Ltd. Cannon toxins in mice by using mice and rats. As a result, it was considered that the toxicity was weak when administered orally, and no semi-lethal amount was obtained in the possible dose. When oral administration, mice and rats generally have the same symptoms of poisoning, that is, sedation is started 30 minutes after taking the drug, and exercise inhibition is suppressed. The beginning of respiration is accelerated, and afterwards, it is inhibited. The paralyzed person is rare and mostly suffocates due to respiratory numbness. The semi-lethal dose at the time of intraperitoneal injection was expressed as follows. Both rats were stable in the range of 14.2 to 17.0 g/kg. There were no significant differences between males and females.