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地塞米松磷酸钠原料药的质量标准自1985年版药典以来,除含量测定由紫外分光光度法改为HPLC法外未见其他变动。我们对其他甾体检查、甲醇与丙酮检查两项进行了方法学的分析及实验,建议修改原标准。1材料与仪器硅胶GF254板(上海信谊仪器厂),地塞米松磷酸钠对照品(0016-9610,中国药品生物制品检定所),地塞米松对照品(0129-9702,中国药品生物制品检定所),地塞米松磷
Dexamethasone sodium phosphate API quality standards since the 1985 edition of the Pharmacopoeia, in addition to the content determination by UV spectrophotometry to HPLC method, no other changes. We conducted other methodological analyzes and experiments on other steroid tests, methanol and acetone tests, and suggested amending the original standards. 1 Materials and equipment Silicone GF254 board (Shanghai Xinyi Instrument Factory), dexamethasone sodium phosphate control (0016-9610, China Pharmaceutical and Biological Products), dexamethasone reference substance (0129-9702, China Pharmaceutical and Biological Products Test ), Dexamethasone phosphorus