近年流行病学、病理形态学和分子遗传学从不同角度揭示了“大肠腺瘤—癌”序列变化过程〔1,2〕,证实腺瘤为癌前病变 〔3〕,对这一癌前病变的研究也越来越受到人们重视。目前关于大肠腺瘤细胞的体外培养 ,国内外报道尚不多 〔4～ 6〕。本研究从人大肠腺瘤组织取材 ,分离培养大肠 In recent years, epidemiology, pathomorphology and molecular genetics revealed from different angles, “Colorectal adenoma - cancer” sequence changes [1,2], confirmed adenoma as precancerous lesions 〔3〕, the precancerous lesions Research is also more and more people’s attention. Currently on the colorectal adenoma cells in vitro culture, not many reports at home and abroad 〔4 ~ 6〕. This study from human colorectal adenoma tissue culture, separation and culture of large intestine