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目的探讨血清单核细胞趋化蛋白-1(MCP-1)、血管内皮生长因子(VEGF)在促进冠状动脉粥样硬化斑块形成及斑块不稳定性中的作用。方法 20名健康体检者为对照组,66例不同程度的冠心病患者为冠心病组(其中包括稳定型心绞痛18例、不稳定型心绞痛24例、急性心肌梗死24例)。采用间接酶联免疫吸附法(ELISA)检测血清中MCP-1、VEGF的浓度,并作比较。结果冠心病组血清MCP-1为(567.54±14.31)pg/ml、VEGF为(491.01±12.06)pg/ml,对照组分别是(203.3±11.83)pg/ml、(141.28±8.67)pg/ml,冠心病组MCP-1、VEGF水平均明显高于对照组,差异有统计学意义(P<0.001)。对冠心病各亚组、对照组各组之间的MCP-1、VEGF水平也进行了比较。MCP-1、VEGF之间的线性相关性分析结果为r=0.888,呈正相关。结论 MCP-1、VEGF在促进冠状动脉粥样硬化斑块形成的过程中起重要作用,并增加了冠状动脉粥样硬化斑块的不稳定性。
Objective To investigate the role of monocyte chemoattractant protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) in promoting coronary atherosclerotic plaque formation and plaque instability. Methods Twenty healthy subjects were selected as the control group. Sixty-six patients with coronary heart disease were selected as coronary heart disease (including 18 patients with stable angina pectoris, 24 patients with unstable angina pectoris and 24 patients with acute myocardial infarction). Serum concentrations of MCP-1 and VEGF were detected by indirect enzyme-linked immunosorbent assay (ELISA) and compared. Results The serum levels of MCP-1 in coronary heart disease group were (567.54 ± 14.31) pg / ml and VEGF were (491.01 ± 12.06) pg / ml respectively, while those in the control group were (203.3 ± 11.83) pg / ml and (141.28 ± 8.67) The levels of MCP-1 and VEGF in CHD group were significantly higher than those in control group (P <0.001). The levels of MCP-1 and VEGF in each group of coronary heart disease and control group were also compared. The linear correlation between MCP-1 and VEGF was r = 0.888, which showed a positive correlation. Conclusion MCP-1 and VEGF play an important role in promoting the formation of coronary atherosclerotic plaque and increase the instability of coronary atherosclerotic plaque.