流行性出血热病毒病因已被证实,但其发病机理尚未完全澄清。为此,本病微血管病理一直是被注目的中心。过去报导的微血管超微病变大都基于较晚期病人尸体脏器标本,加上DIC 的参与,不易判断因果关系。为探讨本病微血管早期损害特点及其发病学,我们采取早期病例皮肤活体标本做电镜观察,发现早期病例皮肤微血管主要是功能性变化。现将初步观察结果报导如下。 The etiology of the epidemic hemorrhagic fever virus has been confirmed, but its pathogenesis has not yet been fully elucidated. To this end, the disease microvascular pathology has been the center of attention. The past reports of microvascular lesions mostly based on the more advanced post-mortem organ samples, coupled with the involvement of DIC, not easy to judge the causal relationship. In order to explore the characteristics of microvascular early lesions and pathogenesis of this disease, we take early cases of skin biopsies to do electron microscopy and found that early cases of skin microvascular mainly functional changes. The preliminary observations are reported below.