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目的利用Meta分析探讨母亲及子代甲硫氨酸合酶还原酶(MTRR)基因A66G多态性与神经管缺陷(NTDs)发生的相关性。方法检索万方数据库、中国知网、中国生物医学文献数据库、中文科技期刊数据库、Pub Med和Web of Science等中英文数据库,检索时间均为自建库至2015年11月。按照纳入标准选取有关母亲和(或)子代MTRR基因A66G多态性与NTDs发生相关的病例对照研究的学术期刊文献及其参考文献,提取相关数据并应用RevMan 5.0和STATA12.0软件进行Meta分析。结果 (1)有关母亲MTRR基因A66G多态性与NTDs发生相关的文献11篇,包括病例组1 284例,对照组2 182例。Meta分析结果显示,在共显性(GG基因型 vs AA基因型)及等位基因遗传模型下合并OR(95%CI)分别为1.55(1.06~2.27)、1.22(1.01~1.47),故母亲GG基因型相对AA基因型、G等位基因相对A等位基因对于子代NTDs的发生有统计学意义。(2)有关子代MTRR基因A66G多态性与NTDs发生相关的文献11篇,包括病例组1 567例,对照组2 621例。Meta分析结果显示,在共显性(AG基因型 vs AA基因型)遗传模型下合并OR(95%CI)为1.47(1.05~2.05),故子代AG基因型相对AA基因型对于NTDs的发生有统计学意义。结论母亲和子代MTRR基因A66G多态性均为NTDs发生的危险因素。
Objective To explore the relationship between the A66G polymorphism of the methionine synthase reductase (MTRR) gene and the development of neural tube defects (NTDs) in the mother and offspring using Meta-analysis. Methods The Chinese and English databases such as Wanfang Database, CNKI, China Biomedical Literature Database, Chinese Science and Technology Periodical Database, Pub Med and Web of Science were searched. The retrieval time was from self-built database to November 2015. According to the inclusion criteria, the academic journals and their references of the case-control study on the relationship between the A66G polymorphism of MTRR gene and the occurrence of NTDs in the mother and / or offspring were selected and the relevant data were extracted and analyzed by Meta-analysis using RevMan 5.0 and STATA12.0 software . Results (1) There are 11 literatures about MTRR gene A66G polymorphism associated with the occurrence of NTDs, including 1 284 cases in the case group and 2 182 cases in the control group. Meta-analysis showed that OR (95% CI) was 1.55 (1.06-2.227) and 1.22 (1.01-1.47) respectively in co-dominant (GG vs AA genotype) and allelic genetic models, GG genotype relative AA genotype, G allele relative A allele for offspring of NTDs were statistically significant. (2) There are 11 articles related to the A66G polymorphism of offspring MTRR gene and the occurrence of NTDs, including 1 567 cases and 2621 cases in the control group. Meta analysis showed that OR (95% CI) was 1.47 (1.05 ~ 2.05) in the co-dominant (AG genotype vs AA genotype) genetic model, so AG genotype relative AA genotype for NTDs There is statistical significance. Conclusion A66G polymorphism of MTRR gene in mothers and offspring is a risk factor for NTDs.