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捷克斯洛伐克使用脊髓灰质炎活疫苗已20余年,控制了脊髓灰质炎的流行。但是在1975～1978年期间,发现儿童中脊髓灰质炎病毒抗Ⅲ型抗体滴度持续下降。为了提高抗体滴度,将原来第1次服用Ⅰ型单价疫苗,后服Ⅱ、Ⅲ型混合疫苗的顺序,改为第1次先服Ⅰ、Ⅱ型混合疫苗后服Ⅲ型单价疫苗。作者观察采用后一种免疫顺序对Ⅲ型病毒在机体内增殖及抗体产生的情况。本研究对象为托儿所儿童,分三组。即初次免疫16名,再次免疫10名及前几年已免
The use of live poliomyelitis vaccine in Czechoslovakia has been in control for more than 20 years and has helped to limit the spread of poliomyelitis. However, between 1975 and 1978, the titers of anti-type III antibodies to poliovirus in children were consistently decreased. In order to improve the antibody titer, the first time to take type I monovalent vaccine, after the service Ⅱ, Ⅲ mixed vaccine sequence, to the first service first, type Ⅱ mixed vaccine type Ⅲ monovalent vaccine. The authors observed the use of the latter immunization sequence for type III virus in vivo proliferation and antibody production. The study object for nursery children, divided into three groups. That is, the initial immunization of 16, re-immunization of 10 and a few years ago have been exempted