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目的 为探讨尼莫地平对新生儿缺氧缺血性脑病(HIE)的治疗作用.方法 将HIE新生儿43例,分为尼莫地平治疗组21例和对照组22例.治疗组于生后12小时内开始使用尼莫地平口服治疗5mg/(kg.d),每日分2次,疗程5天.其余治疗和处理两组相同,于生后12小时、24小时、72小时检测RBCTCa和Ca~(2+)i的含量,并于后后3日,7日行新生儿行为神经测定(20项NBNA评分).结果 显示对照组12h,24h,RBCTCa和Ca~(2+)i均高于治疗各时相组,差异有显著性意义(P<0.01).两组患儿生后3日20项NBNA评分均明显低于正常,两组间无统计学差异.生后7日20项NBNA评分治疗组明显高于对照组(P<0.001).结论 早期使用尼莫地平能阻止Ca~(2+)内流,从而达到保护神经元,改善临床症状的作用
Objective To investigate the therapeutic effect of nimodipine on neonatal hypoxic-ischemic encephalopathy (HIE) .Methods 43 neonates with HIE were divided into nimodipine-treated group (n = 21) and control group (n = 22) Within 12 hours, nimodipine was given orally for 5 mg / (kg · d) orally, twice daily for 5 days.The remaining two groups were treated and treated the same way, and RBCTCa was detected at 12 hours, 24 hours and 72 hours after birth (Ca2 +) i content in the neonatal and neonatal behavioral nerves (20 NBNA scores) on the 3rd and 7th day after the operation.The results showed that both RBCTCa and Ca2 + (P <0.01) .Twenty NBNB scores of the two groups were significantly lower than those of the normal group on the 3rd postnatal day 3, with no significant difference between the two groups NBNA score was significantly higher in the treatment group than in the control group (P <0.001) .Conclusion Early use of nimodipine can prevent Ca 2+ influx and thus protect neurons and improve clinical symptoms