The test on the model with data collected from two years’ field experiments revealed an ability to satisfactorily simulate crop parameters such as LAI, biomass accumulation and partitioning, yield, and variables influencing crop growth and development as nitrogen uptake by crops and partitioning in different organs, and dynamics of soil water and nitrogen including infiltration and leaching. With the model, crop yield, water use efficiency (WUE), nitrogen use efficiency (NYE) and water-nitrogen leaching at specific soil layers under various water and nitrogen management practices were simulated to provide data used as references for designing sustainable nitrogen and water management practices. The outputs of the simulated experiment with various treatments of irrigation and nitrogen application indicated that crop yield was closely related to water and nitrogen application, crop water use was positively related to irrigation amount, and nitrogen fertilization could improve the crop water use and WUE within certain limits. This is a valuable evidence to be considered in water-saving farming. Nitrogen uptake had a positive relation to nitrogen application, while irrigation to some extent improved its uptake by crops and hence increased NYE. Additionally, irrigation and fertilization had great effects on nitrogen leaching. Thus, in order to improve WUE and NYE, the model showed how nitrogen application and irrigation should be well coordinated.