垂体腺瘤是颅内常见的良性肿瘤 ,约 1 / 3呈侵袭性生长 ,手术难以全切除 ,术后易复发 ,成为临床治疗的难点。临床上区分侵袭性和非侵袭性垂体腺瘤一般根据临床表现、影像学检查、术中所见及病理学检查 ,但均难以全面反映其生物学行为[1 ] 。如何从分子水平来了解侵袭性垂体腺瘤 Pituitary adenoma is a common intracranial benign tumor, about 1/3 was invasive growth, surgical resection is difficult to complete, easy to relapse after surgery, a clinical treatment of the difficulties. Clinical distinction between invasive and non-invasive pituitary adenomas is generally based on clinical manifestations, imaging studies, intraoperative findings and pathological examination, but are difficult to fully reflect the biological behavior [1]. How to Understand Invasive Pituitary Adenoma at Molecular Level