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目的研究乐卡地平联合依那普利治疗高血压早期肾损害的疗效。方法 106例高血压早期肾损害患者,根据治疗方法的不同分为研究组(58例)和对照组(48例)。研究组患者采用乐卡地平联合依那普利治疗,对照组患者采用依那普利治疗。比较两组患者肾功能指标、血压状况。结果治疗后,研究组患者微量清蛋白(MA)、血尿素氮(BUN)、血肌酐(SCr)、尿微量白蛋白(mALB)水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后,研究组患者舒张压(DBP)、收缩压(SBP)水平分别为(82.47±7.02)、(133.66±7.35)mm Hg(1 mm Hg=0.133 k Pa),均低于对照组的(88.92±7.56)、(144.98±6.83)mm Hg,差异具有统计学意义(P<0.05)。结论高血压早期肾损害患者行乐卡地平联合依那普利治疗可降低血压水平,改善肾功能,值得推广。
Objective To study the efficacy of lercanidipine and enalapril in the treatment of early renal damage in patients with hypertension. Methods A total of 106 patients with early renal damage caused by hypertension were divided into study group (58 cases) and control group (48 cases) according to the different treatment methods. The study group was treated with lercanidipine plus enalapril and the control group with enalapril. The renal function, blood pressure were compared between the two groups. Results After treatment, the levels of MA, BUN, SCr and mALB in the study group were lower than those in the control group (P <0.05) ). After treatment, the DBP and SBP in the study group were (82.47 ± 7.02) and (133.66 ± 7.35) mm Hg (1 mm Hg = 0.133 kPa), respectively, which were lower than those in the control group 88.92 ± 7.56), (144.98 ± 6.83) mm Hg, the difference was statistically significant (P <0.05). Conclusions Leprodipine combined with enalapril can reduce blood pressure and improve renal function in patients with early stage of renal hypertension. It is worth promoting.