论文部分内容阅读
目的 探讨当前流行的严重急性呼吸道综合征 (SARS)的若干临床特点。方法 回顾性统计分析广州南方医院收治的 85例SARS患者的临床资料。结果 85例SARS患者的年龄在 4～ 87岁 ,平均 ( 38.2± 16 .7)岁 ,男 41例 ,女 44例。该病的潜伏期为 2～ 16d ,平均为 ( 7.4± 3 .8)d ;主要临床表现有发热 ( 97.6 %)、咳嗽 ( 81.2 %)、乏力 ( 74.1%)、头痛 ( 6 3 .5 %)、肌肉酸痛 ( 41.2 %) ;热程多为 4～ 12d( 81.9%) ,平均热程为 ( 7.8± 3.5 )d ;外周血白细胞计数正常或降低 ( 82 .4%) ,淋巴细胞计数减少 ( 2 7.1%) ;血液生化示丙氨酸转氨酶升高 ( 44 .7%) ,天门冬氨酸转氨酶升高 ( 5 7.6 %) ,乳酸脱氢酶升高 ( 49.4%) ,肌酸磷酸激酶升高 ( 2 0 %) ;肺部X线摄片主要表现为片状或斑片状炎症渗出( 85 .9%) ,少数表现为间质性炎症改变 ( 14.1%) ;炎症多位于双侧下肺 /中下肺 ( 5 1.8%) ,其次为单侧下肺 /中下肺 ( 36 .5 %) ;发病至肺炎症渗出完全吸收的平均时间为 ( 2 0 .3± 8.4)d ,热退后至肺炎症渗出完全吸收的平均时间为 ( 13 .1± 6 .9)d ;经验性治疗为 :病毒唑、对症支持治疗及应用广谱抗生素。结论 SARS具有传染性 ,发热、咳嗽、胸片示肺部炎症表现及外周血白细胞正常或降低是该综合征的临床特点。
Objective To investigate the clinical features of the current epidemic of severe acute respiratory syndrome (SARS). Methods The clinical data of 85 SARS patients admitted to Guangzhou Nanfang Hospital were retrospectively analyzed. Results The age of 85 patients with SARS was 4-87 years (mean: 38.2 ± 16.7) years, 41 males and 44 females. The clinical manifestations were fever (97.6%), cough (81.2%), fatigue (74.1%), headache (65.3%), , Muscle soreness (41.2%); the main thermal course was 4 ~ 12 days (81.9%), the average heat history was (7.8 ± 3.5) days; the peripheral blood leukocyte count was normal or decreased (82.4% 2 7.1%); blood biochemistry showed elevated alanine aminotransferase (44.7%), aspartate aminotransferase increased (7.66%), lactate dehydrogenase increased (49.4%), creatine phosphokinase l High (20%); pulmonary X-ray showed mainly flake or patchy inflammatory exudate (85.9%), a small number showed interstitial inflammation (14.1%); inflammation in the bilateral The average time of complete absorption from the onset to pneumonia exudation was (20.3 ± 8.4) days , And the average time from fever to pneumonia exudation completely absorbed was (13.1 ± 6.9) days. The empirical treatment was ribavirin, symptomatic supportive therapy and the application of broad-spectrum antibiotics. Conclusion SARS is contagious, fever, cough, lung manifestations of chest inflammation and normal or decreased peripheral white blood cells is the clinical features of the syndrome.