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目的回顾性统计分析本院临床药学对甲氨蝶呤血药浓度监测结果,为儿科临床合理用药提供参考。方法用荧光偏振免疫法(FPIA)测定血药浓度。结果甲氨蝶呤2008～2010年间进行血药浓度监测,321例次甲氨蝶呤监测中,未中毒共有258例次,占80.4%;中毒共有28例次,占8.7%。结论血药浓度监测是指导临床用药的依据之一,提示临床加强治疗药物监测重要性和必要性的认识,实行个体化给药,保证患者用药安全、有效、发挥药物的最佳效应。
Objective To retrospectively analyze the monitoring results of methotrexate plasma concentration in clinical pharmacy in our hospital and provide a reference for clinical pediatric rational drug use. Methods Fluorescence polarization immunoassay (FPIA) was used to determine plasma concentration. Results Methotrexate was monitored during 2008-2010. Of the 321 cases of methotrexate monitored, 258 were non-poisonous, accounting for 80.4% of the total; and 28 were poisoned, accounting for 8.7%. Conclusion The monitoring of blood concentration is one of the bases for guiding the clinical medication. It suggests that clinical monitoring of the importance and necessity of therapeutic drug monitoring should be intensified. Individualized drug administration should be implemented to ensure that the medication is safe and effective and the optimal effect of the drug is exerted.