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目的:探讨代谢综合征与BPH的相关性。方法:将伴有下尿路症状的246例老年BPH患者根据有无代谢综合征分成两组:Ⅰ组伴有代谢综合征患者139例,Ⅱ组不伴代谢综合征患者107例,测量体质指数(BMI)、血压、腰围,根据下尿路症状进行国际前列腺症状评分(IPSS)。所有患者检查空腹血糖(FBG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、空腹胰岛素水平(FINS)、糖化血红白水平(HbA1c)、餐后血糖(PBG)及前列腺特异抗原(PSA),计算胰岛素抵抗指数(HOMA-IR)。经腹部超声测量前列腺三径计算前列腺体积(PV)。结果:老年BPH患者高血压、冠心病、糖尿病的患病率高,代谢综合征组患者BMI、SBP、FBG、PBG、LDL-C、TG、FINS、HbA1c及PV较对照组显著升高,且存在胰岛素抵抗,差异具有统计学意义(P<0.05)。结论:老年BPH患者存在胰岛素抵抗,研究表明代谢综合征可能促进BPH。因此,改善胰岛素抵抗可能对预防BPH有一定作用。
Objective: To investigate the correlation between metabolic syndrome and BPH. Methods: The 246 elderly BPH patients with lower urinary tract symptoms were divided into two groups based on the presence or absence of metabolic syndrome: group Ⅰ with 139 patients with metabolic syndrome, group Ⅱ with 107 patients without metabolic syndrome, body mass index (BMI), blood pressure, waist circumference, and International Prostate Symptom Score (IPSS) based on lower urinary tract symptoms. All patients had fasting blood glucose (FBG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), fasting insulin (FINS) HbA1c), postprandial blood glucose (PBG) and prostate specific antigen (PSA) were calculated and insulin resistance index (HOMA-IR) was calculated. Prostate volume (PV) was calculated by measuring the diameter of the prostate by abdominal ultrasonography. Results: The prevalence rate of hypertension, coronary heart disease and diabetes was high in elderly BPH patients. The BMI, SBP, FBG, PBG, LDL-C, TG, FINS, HbA1c and PV in patients with metabolic syndrome were significantly higher than those in controls There was insulin resistance, the difference was statistically significant (P <0.05). CONCLUSION: Insulin resistance is present in elderly BPH patients and studies suggest that metabolic syndrome may promote BPH. Therefore, improving insulin resistance may play a role in preventing BPH.