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目的 观察国产降纤酶治疗脑梗死的临床疗效、毒副作用以及对血浆纤维蛋白原、凝血酶原时间的影响。 方法 对 CT或 MRI确诊的脑梗死病人 33例 ,按随机方法分为治疗组与对照组 ,分别于治疗前后测定神经功能缺损评分、纤维蛋白原、凝血酶原时间及肝、肾功能并进行对比分析。 结果 降纤酶治疗后神经功能缺损明显改善 ( P <0 .0 0 1 )并且治疗后 1天即出现明显效果 ( P <0 .0 0 5 ) ,总有效率明显高于对照组 ( P <0 .0 5 ) ;血浆纤维蛋白原明显下降 ,与对照组相比 P <0 .0 5 ;治疗过程中未见不良反应。 结论 降纤酶治疗脑梗死疗效显著 ,起效快 ,较安全。
Objective To observe the clinical curative effect, toxicity and side effects of domestic defibrase on cerebral infarction and its effect on plasma fibrinogen and prothrombin time. Methods Thirty-three patients with cerebral infarction diagnosed by CT or MRI were randomly divided into treatment group and control group. Neurological deficit score, fibrinogen, prothrombin time, liver and kidney function were measured before and after treatment analysis. Results After defibrase treatment, the neurological deficit was significantly improved (P <0.01) and the obvious effect was observed on the 1st day after treatment (P <0.05). The total effective rate was significantly higher than that of the control group (P < 0. 0 5); Plasma fibrinogen was significantly decreased compared with the control group P <0. 05; no adverse reactions in the course of treatment. Conclusion Defibrase treatment of cerebral infarction significant effect, rapid onset, safer.