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目的:探讨口服咪达唑仑对接受局部麻醉牙齿修复治疗患儿唾液皮质醇水平的影响。方法:选取2012年4月至2015年12月于我院接受局部麻醉牙齿修复的患儿104例为研究对象,随机分为A、B两组各52例。A组患儿给予口服1.0 mg/kg咪达唑仑糖浆,B组患儿给予口服同等剂量的安慰剂,监测患儿入院前一天晨起时、入院当日晨起时、入院时、麻醉后25 min及修复治疗后25 min的唾液皮质醇水平,记录患儿的心率及血氧饱和度等参数,评估患儿的行为表现。结果:A组患儿接受咪达唑仑麻醉后25 min的唾液皮质醇水平为(0.48±0.19)μg/d L,低于B组的(1.06±0.21)μg/d L,差异有统计学意义(P<0.05)。其他时间点唾液皮质醇水平组间比较差异无统计学意义(P>0.05),且麻醉方式对患儿唾液皮质醇含量无明显影响。在麻醉和治疗期间,唾液皮质醇水平与患儿挣扎状态(俄亥俄州立大学行为评定量表法)无显著相关性(P>0.05)。结论:口服咪达唑仑能够降低牙齿修复术患儿局部麻醉期间唾液皮质醇水平,但不影响患儿的临床行为。
Objective: To investigate the effect of oral midazolam on saliva cortisol levels in children undergoing partial denture repair. Methods: A total of 104 children undergoing local anesthesia for dental restoration in our hospital from April 2012 to December 2015 were selected and randomly divided into two groups (A and B). Group A children given oral 1.0 mg / kg midazolam syrup, group B children given the same dose of oral administration of placebo, the monitoring of children from the day before admission on the morning, the morning of admission day, admission, anesthesia 25 min and salivary cortisol levels 25 minutes after the repair, the parameters such as heart rate and oxygen saturation were recorded and the performance of children was evaluated. Results: The salivary cortisol level in group A was (0.48 ± 0.19) μg / dL at 25 min after anesthesia, lower than that in group B (1.06 ± 0.21) μg / d L, the difference was statistically significant Significance (P <0.05). There was no significant difference in salivary cortisol levels between the other time points (P> 0.05), and the anesthetic mode had no significant effect on salivary cortisol levels in children. There was no significant correlation between salivary cortisol levels and children’s struggling status (Ohio State University Behavior Rating Scale) during anesthesia and treatment (P> 0.05). Conclusions: Oral administration of midazolam can reduce salivary cortisol levels during local anesthesia in children undergoing dental restorations but does not affect the clinical behavior in children.