对４７６例初治涂阳肺结核病人，在三种短程化疗方案２ＨＲＺＳ／４ＨＲ、２ＨＲＺＳ／４Ｈ３Ｒ３和２Ｈ３Ｒ３Ｚ３Ｓ３／４Ｈ３Ｒ３治疗全程管理下进行疗效观察。结果疗程结束时痰菌阴转率分别为９８．７％、９８．１％和９８．１％，２年随访复发率分别为１．９％、２．０％和２．６％，三种方案疗效差异无显著性。认为：①６个月全间歇短程方案用药次数少，节省了费用，有利于管理，值得临床推广；②由于间歇服药时单次剂量偏大，所以毒副作用相对较多，应加强访视及对症处理。 476 cases of newly diagnosed smear-positive pulmonary tuberculosis patients under the three short-course chemotherapy regimens 2HRZS / 4HR, 2HRZS / 4H3R3 and 2H3R3Z3S3 / 4H3R3 treatment throughout the management of efficacy. Results The sputum negative conversion rates were 98.7%, 98.1% and 98.1% at the end of the course of treatment. The recurrence rates at 2 years follow-up were 1.9%, 2.0% and 2.6%, respectively No significant difference in the efficacy of the program. It is concluded that: (1) the 6-month full-dose short-course regimen has less medication times, which saves costs and is beneficial to management and worthy of clinical promotion; (2) due to the large single dose during intermittent medication, the side effects are relatively more and should be intensified for visits and symptomatic treatment .