许多无机粉尘,如SiO_2、石棉等均可致肺纤维化。在纤维化过程中,必然涉及肺胶原蛋白的合成增加。因此,以往通常以测定肺组织胶原含量作为评价纤维化的一个指标。然而,在纤维化达到某种程度的肺组织中,胶原含量却仍在正常范围。最近研究发现肺组织和血液中某些与胶原合成有关的酶活性在纤维化早期即明显增高。为此,本文作者选用致纤维化活 Many inorganic dusts, such as SiO_2, asbestos, etc. can cause pulmonary fibrosis. In fibrosis, the synthesis of lung collagen must be involved. Therefore, in the past, the lung tissue collagen content was usually used as an index for evaluating fibrosis. However, collagen levels are still in the normal range in fibrosis to some extent in lung tissue. Recent studies found that some of the lung tissue and blood enzymes related to collagen synthesis in the early stage of fibrosis was significantly increased. To this end, the author chose to lead to fibrosis