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目的探讨HIV感染者在接受抗病毒治疗后身体健康的改善情况及其影响因素。方法选择湖北省HIV感染率和AIDS患病率较高的襄樊和随州两市作为目标社区,采用问卷调查的形式,调查了84例目前正在接受抗病毒治疗的HIV感染者。结果抗病毒治疗后患者个人感觉明显改善居前三位的依次是食欲增强(64.3%)、更有活力(56.0%)、睡眠更好(56.0%);患者身体状况的总体感觉在治疗前后有显著性差异(t=8.572,P=0.001);对抗病毒治疗持续时间与健康状况总指标作相关性分析发现两者存在负线性相关(r=-0.51,P=0.037),即随着抗病毒治疗持续时间的延长,患者健康状况总指标的得分降低。不同服药依从性得分的患者健康状况总指标的差异有统计学意义(F=2.375,P=0.036)。结论抗病毒治疗后,HIV感染者身体的总体健康状况得到显著改善,但治疗时间的延长限制了患者健康状况的进一步提高。
Objective To investigate the improvement of physical health of HIV-infected patients after antiviral therapy and its influencing factors. Methods Eighty-three HIV-infected patients currently undergoing antiviral therapy were surveyed in Xiangfan and Suizhou, which have a high HIV prevalence and high prevalence of AIDS in Hubei Province, as the target community by questionnaire. Results After the antiviral treatment, the patients’ personal feeling improved obviously. Among the top three, appetite enhancement (64.3%), more vitality (56.0%) and better sleep (56.0%) were observed. The overall physical condition of the patients had (T = 8.572, P = 0.001). Correlation analysis between the duration of antiretroviral treatment and general indicators of health status showed a negative linear correlation (r = -0.51, P = 0.037) Prolonged treatment duration decreased the overall score of the patient’s health status. There were significant differences in the total health status of patients with different medication compliance scores (F = 2.375, P = 0.036). Conclusion The overall health status of HIV-infected individuals has been significantly improved after antiviral treatment, but the prolonged treatment time limits the patient’s health.