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目的分析幽门螺杆菌(Helicobacter pylori,HP)根除治疗失败相关因素,为有效根除Hp提供建议和决策。方法对2005年5月2008年12月经胃镜检查确诊的慢性胃炎或消化性溃疡,且Hp检测阳性并行含质子泵抑制剂三联或四联治疗的患者103例进行研究。治疗结束至少4周后,用14C呼气试验评估Hp是否成功根除,根据测试结果分为治疗失败组33例及治疗成功组70例。运用统一标准的调查表对每位患者进行相关因素调查,就调查表所涉及的因素在根除失败组与成功组间采用单因素及多因素Logistic回归进行分析。结果通过单因素分析依从性和饮酒在两组之间有统计学意义(P<0.05)。Logistic多因素分析发现,依从性差是根除失败的独立危险因素。结论依从性差是治疗失败十分重要的影响因素。
Objective To analyze the factors related to the failure of Helicobacter pylori (HP) eradication therapy and provide suggestions and decisions for the effective eradication of Hp. Methods A total of 103 patients with chronic gastritis or peptic ulcer diagnosed by gastroscopy in May 2005 and diagnosed by gastroscopy were enrolled in this study. 103 patients with positive Hp test and triple or quadruple proton pump inhibitor therapy were studied. At least 4 weeks after the end of treatment, 14C breath test was used to evaluate the successful eradication of Hp. According to the test results, 33 patients were divided into treatment failure group and 70 patients successfully treated. Using a uniform standard questionnaire for each patient related factors survey, the questionnaire involved in the eradication failure group and the successful group using single factor and multivariate Logistic regression analysis. Results One-way analysis of adherence and alcohol consumption was statistically significant between the two groups (P <0.05). Logistic multivariate analysis found that poor compliance was an independent risk factor for eradication failure. Conclusion Poor compliance is a very important factor in the failure of treatment.