在代谢协同作用的研究中,哺乳动物的晶状体在器官水平对裂隙连接与细胞间通讯的作用是惟一的。晶状体无血管,依赖高度发达的由裂隙连接介导的细胞间通讯网络来调控其离子和代谢物的交换。细胞质中的pH、细胞内Ca~(2+)的浓度及蛋白质磷酸化可调控裂隙连接的通透性。连接蛋白的表达和构象的改变影响裂隙连接的通透性,从而改变细胞间通讯。目前认为裂隙连接在晶状体细胞的营养、代谢和保持晶状体透明性中起关键作用。 In the study of metabolic synergy, the role of the mammalian lens at the organ level on fracture junction and cell-cell communication is unique. The lens is avascular and regulates the exchange of ions and metabolites by virtue of a highly developed cell-cell communication network mediated by the fissure junction. The pH in the cytoplasm, the concentration of intracellular Ca ~ (2+) and the phosphorylation of the protein regulate the permeability of the cleft junction. Changes in connexin expression and conformation affect the permeability of the cleft junction, thereby altering the intercellular communication. It is currently believed that the fissure junction plays a key role in the nutrition, metabolism, and lens clarity of the lens cells.