目的:比较不同气腹压力下妇科腹腔镜手术患者血清炎症细胞因子IL-1的动态变化,探讨妇科腹腔镜手术对细胞炎症因子的影响。方法:选择行腹腔镜患者60例,所有患者随机分为高气腹组(15 mmHg),中气腹组(12 mmHg),低气腹组(9 mmHg),每组20例,术前、术中(气腹30 min后)、术后12 h抽取静脉血,采用酶联免疫吸附双抗体夹心法(ELISA)测定血清IL-1水平。结果:高气腹组术后胃胀气、恶心呕吐的发生率明显高于低、中气腹组。三组患者血清IL-1的水平在术前均无统计学差异,术后血清IL-1水平都出现下降;但术中高、中气腹组的血清IL-1水平显著高于低气腹组(P<0.05);术后中气腹组与低气腹组之间IL-1水平无统计学差异,而高气腹组的血清IL-1水平仍然显著高于另外两组(P<0.05)。结论:中、低气腹压力对组织的损伤较小,更有利于损伤的修复,在手术条件允许的情况下尽量选用中、低气腹压力。 Objective: To compare the dynamic changes of serum inflammatory cytokines IL-1 in patients undergoing pneumoperitoneum under pneumoperitoneal pressure and to explore the effect of gynecological laparoscopic surgery on inflammatory cytokines. Methods: Sixty patients undergoing laparoscopy were selected. All patients were randomly divided into high pneumoperitoneum group (15 mmHg), moderate pneumoperitoneum group (12 mmHg), low pneumoperitoneum group (9 mmHg) Intraoperatively (after 30 min of pneumoperitoneum), venous blood was drawn 12 h after operation, and serum IL-1 level was measured by enzyme-linked immunosorbent assay (ELISA). Results: The incidence of flatulence and nausea and vomiting in patients with high pneumoperitoneum was significantly higher than those in patients with low and moderate pneumoperitoneum. Serum levels of IL-1 in three groups had no significant difference before operation and serum IL-1 levels decreased after operation. However, serum IL-1 levels in high and middle pneumoperitoneum group were significantly higher than those in low-pneumoperitoneum group (P <0.05). There was no significant difference in the level of IL-1 between the pneumoperitoneum and the pneumoperitoneum group, but the level of IL-1 in the pneumoperitoneum group was still significantly higher than the other two groups (P <0.05) ). CONCLUSION: Middle and low pneumoperitoneal pressure have less damage to the tissue, which is more conducive to the repair of the injury. When the operating conditions permit, try to choose the medium and low pneumoperitoneum pressure.