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强效安定剂氟哌啶的合成过程中,有两步反应较为重要,一为氢化切苄反应,需完全切除苄基而不致氢化双键,故必须严格控制用氢量和反应温度;二为最后一步脱氯化氢反应,按专利方法,反应时闻长,副产物多,经改进后,采用薄层层析法随时检查反应液中杂质生成的情况,使反应时间大为缩短,并可减少副产物的生成。本品熔点147.5～149.5℃。经核磁共振和质谱分析,证实产物结构确凿;红外及紫外光谱也与文献报道一致。
Potent stabilizer haloperidol in the synthesis process, two-step reaction is more important, one for the hydrogenated benzyl reaction, the need to completely remove the benzyl without hydrogenated double bonds, it is necessary to strictly control the amount of hydrogen and the reaction temperature; two The final step of dehydrochlorination reaction, according to the patented method, when the reaction smell long, many by-products, after the improvement, the use of thin-layer chromatography at any time check the reaction solution of impurities generated, the reaction time is greatly reduced, and can reduce the number of vice Product generation. This product melting point 147.5 ~ 149.5 ℃. Nuclear magnetic resonance and mass spectrometry confirmed that the product structure is conclusive; infrared and ultraviolet spectroscopy also reported in the literature.