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在乙型肝炎病毒(HBV)感染病人中,肝病的严重程度有明显差异,临床上很难解释。关于乙型肝炎的发病机理,以前的研究主要集中于宿主的免疫反应方面。近年来,由于分子生物学技术的发展,多聚酶链反应(PCR)技术、分子克隆及序列分析等先进手段的出现,病毒的基因变异逐渐引起重视。目前研究认为HBV的基因变异与乙型肝炎临床表现多样化有密切关系。 HBV基因有4个开放读码框架(ORF)。S区编码病毒的外膜蛋白(HBsAg),C区编码病毒的两种核心蛋白(HBeAg)(HBcAg),P区编码病毒逆转录
In patients with hepatitis B virus (HBV) infection, the severity of liver disease there are significant differences, it is difficult to explain clinically. With regard to the pathogenesis of hepatitis B, previous studies have focused mainly on the host’s immune response. In recent years, due to the development of molecular biology technology, polymerase chain reaction (PCR) technology, molecular cloning and sequence analysis and other advanced means of emergence, the gene mutation of the virus has gradually attracted attention. The current study that the genetic variation of HBV and the clinical manifestations of hepatitis B is closely related to the diversification. The HBV gene has four open reading frames (ORFs). The outer membrane protein (HBsAg) encoding the virus in S region, the two core proteins (HBeAg) encoding the virus in region C (HBcAg), the P region coding for virus reverse transcription