侵袭性致病菌引发肠道感染是腹泻的重要原因。病原菌引发人类泻腹的机制包括:1.产生肠毒素;2.产生细胞毒素导致细胞损伤和炎症反应;3.粘附于肠粘膜上;4.导致粘膜炎症及粘膜溃疡。以上四种机制均可刺激肠上皮细胞分泌水和电解质增加。本文着重介绍抗生素治疗侵袭性致病菌所致腹泻的当前进展。 Invasive pathogenic bacteria cause intestinal infection is an important cause of diarrhea. Mechanism of pathogens causing human laxatives include: 1. producing enterotoxins; 2. producing cytotoxins leading to cell damage and inflammatory responses; 3. adhering to the intestinal mucosa; 4. causing mucosal inflammation and mucosal ulceration. The above four mechanisms can stimulate intestinal epithelial cells to secrete increased water and electrolytes. This article highlights current advances in antibiotic treatment of invasive diarrhea caused by invasive pathogens.