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局部缺血和肾中毒引起的急性肾功能衰竭（ＡＲＦ）的恢复，需要有新生的小管细胞替换受损伤的小管细胞，来恢复肾上皮的连续性，修复过程涉及到肾组织产生的一些生长因子，这些生长因子在修复过程中参与自分泌或旁分泌调节。
Rehabilitation of acute renal failure (ARF) caused by ischemia and nephrotoxicity requires the replacement of damaged tubule cells by nascent tubules to restore the continuity of the renal epithelium. The repair process involves the growth of some of the growth factors in the kidney , These growth factors are involved in autocrine or paracrine regulation during repair.