脂肪萎缩症又称脂肪萎缩综合征,是一种非常罕见的疾病,典型的表现为皮下脂肪组织的缺乏,包括广泛受累和局部受累,伴或不伴非萎缩部位的脂肪组织异常堆积,常合并胰岛素抵抗、血糖代谢异常、血脂代谢异常、高血压、脂肪肝等多种代谢紊乱。具体分子机制还未明确。目前很多研究证实一些基因异常可导致脂肪萎缩。1脂肪萎缩的分型脂肪萎缩分型较复杂,按照疾病来源,可分为先天性、家族性脂肪萎缩和获得性脂肪萎缩;按照部 Lipoid atrophy, also known as lipoatrophy syndrome, is a very rare disease that is typically characterized by a deficiency of subcutaneous adipose tissue, including extensively and locally involved, abnormal accumulation of adipose tissue with or without non-atrophic sites, often combined Insulin resistance, abnormal glucose metabolism, dyslipidemia, hypertension, fatty liver and other metabolic disorders. The specific molecular mechanism is not yet clear. At present, many studies have confirmed that some genetic abnormalities can lead to lipoatrophy. 1 lipoatrophy type lipoatrophy typing is more complicated, according to the source of the disease can be divided into congenital, familial lipoatrophy and acquired lipoatrophy; according to the Department