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目的评价疑诊新生儿早发脓毒症(early-onset sepsis,EOS)经验性抗生素应用的合理性。方法对重庆医科大学附属儿童医院新生儿中心病房2015-6-01—2015-07-31入院即怀疑EOS者抗生素应用情况进行回顾性分析。按其确诊结果分为非脓毒症组和脓毒症组,主要调查抗生素应用情况。结果疑诊的217例中非脓毒症组122例、脓毒症组95例。入院首选抗生素为青霉素+拉氧头孢,其中非脓毒症组占68.4%,脓毒症组占64.5%。非脓毒症组抗生素初始阶段(<3 d)不合理应用有16例(13.1%),抗生素持续阶段(≥3 d)不合理应用有77例(63.1%)。脓毒症组抗生素初始阶段不合理应用有9例(9.5%),抗生素持续阶段不合理应用有49例(51.6%)。结论疑诊EOS的抗生素不合理应用情况较严重,需要建立新生儿抗生素管理团队,协助指导新生儿病房EOS抗生素的规范应用。
Objective To evaluate the rationality of using empirical antibiotics in suspected neonatal early-onset sepsis (EOS). Methods Children’s Hospital of Chongqing Medical University neonatal wards 2015-6-01-2015-07-31 hospitalized suspected antibiotics EOS application were retrospectively analyzed. According to the diagnosis results are divided into non-sepsis group and sepsis group, the main investigation of antibiotic application. 217 cases of suspected sepsis in the septic group 122 cases, sepsis group 95 cases. The antibiotics preferred for admission were penicillin + deoxythiazoxe, of which 68.4% were in non-sepsis group and 64.5% in sepsis group. There were 16 cases (13.1%) of unreasonable use of antibiotics in the non-sepsis group (<3 days) and 77 cases (63.1%) of unreasonable use of antibiotics in the continuous phase (≥3 days). In the sepsis group, 9 cases (9.5%) were irrationally used in the initial stage of antibiotics and 49 cases (51.6%) were unreasonable in the continuous stage of antibiotics. Conclusion Suspected EOS unreasonable application of antibiotics more serious need to establish a neonatal antibiotic management team to help guide the standardized application of neonatal ward EOS antibiotics.