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本文首次报道两例因同时使用溶伐斯丁(Levas-tatin)和华法令(Warfarin)而引起低凝血酶原症和出血。病例1:男,48岁,患有慢性房颤,用华法令预防血栓。医嘱病人严格低胆固醇饮食,坚持锻炼,并每天口服华法令5mg,此时病人凝血酶原时间变化范围为18～24see,血清胆固醇只降到8.2mmol/L.每天增加了20mg的洛伐斯丁,3w后病人由于患有轻微直畅出血而被诊断为患低凝血酶原症,出血是由于洛伐斯丁和华法令的相互作用引起的。随将华法令减少到2mg/d,72h后出血症状消失。坚持12w的洛伐斯丁治疗,病人的胆固醇水平下降到4.3mmol/L.病例2:男,58岁,患有脑血栓。用5mg华法令后,测得凝血酶原时间为19～22sec,无出血倾向,但
This is the first report of two cases of low prothrombinosis and bleeding caused by the simultaneous use of Levas-tatin and warfarin. Case 1: Male, 48 years old, with chronic atrial fibrillation, warfarin to prevent thrombosis. The doctor ordered the patient strictly low cholesterol diet, insist on exercise, and daily oral warfarin 5mg, this time the patient’s prothrombin time range of 18 ~ 24see, serum cholesterol dropped to 8.2mmol / L. Daily increased 20mg of lovastatin After 3 weeks, the patient was diagnosed as having low prothrombin due to a slight and straight haemorrhage due to the interaction between lovastatin and warfarin. With warfarin reduced to 2mg / d, 72h after the disappearance of bleeding symptoms. Sticking to Losvastatin for 12 weeks, the patient’s cholesterol level dropped to 4.3 mmol / L. Case 2: Male, 58 years old with cerebral thrombus. After 5 mg of warfarin, the prothrombin time was 19-22 sec, with no bleeding tendency