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为了探讨组织胺_2(H_2)拮抗物在变应性鼻炎中的作用,作者以前曾提出一种假说,即H_2拮抗物是通过调节T-抑制淋巴细胞的活性而产生效应的。为了证实这一观点,作者对20名变应性鼻炎的病人进行了研究。男女各半,平均年龄23岁(12～43岁),都经试验证实具有典型的花粉过敏史,在研究前至少已有2个月未经任何治疗。受检者分成两组,每组10人,年龄性别相近。组Ⅰ静脉注射H_2拮抗物(3mg/kg/日,共15次);组Ⅱ静脉注射安慰剂。用免疫酶方法测定血清中IgE总量。此外用家兔补体和单克隆抗体补体依赖性细胞毒试验方法,确定治疗前后从外周血液中分离的T-淋巴细胞亚群。
To investigate the role of histamine-2 (H 2) antagonists in allergic rhinitis, the authors previously proposed a hypothesis that H 2 antagonists exert their effects by modulating T-inhibited lymphocyte activity. To confirm this view, the authors studied 20 patients with allergic rhinitis. Half of men and women, mean age 23 years (12 to 43 years old), have been tested to have a typical history of pollen allergies, at least two months before the study without any treatment. Subjects were divided into two groups, each group of 10 people, age and gender similar. Group Ⅰ intravenous H 2 antagonist (3mg / kg / day, a total of 15 times); Group Ⅱ intravenous placebo. The amount of IgE in serum was measured by the immunoenzyme method. In addition, rabbit complement and monoclonal antibody complement-dependent cytotoxicity assay was used to determine T-lymphocyte subsets isolated from peripheral blood before and after treatment.