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根据自身免疫性甲状腺疾病发病机制新的独特型—抗独特型免疫网络学说，用兔抗人ＴＳＨＡｂ检测ＴＳＨ抗独特型抗体（ＴＳＨＡｂ２）。以正常人为对照，以其结合率ｘ＋２ｓ为正常值上限，大于此值为阳性。６０例ＴＲＡｂ阳性病人中，６５％病人ＴＳＨＡｂ２阳性，而４０例ＴＲＡｂ阴性病人中，只有５％病人ＴＳＨＡｂ２阳性。两组差异显著（Ｐ＜０．０５）。ＴＲＡｂ阳性组中，ＴＲＡｂ和ＴＳＨＡｂ２呈正相关（ｒ＝０．６４５，Ｐ＜０．０１）。同时用制备的ＴＳＨ抗体吸附ＴＲＡｂ阳性血清后再检测ＴＲＡｂ，吸附前后差异显著（Ｐ＜０．０５）．抗ＴＲＡｂ抗体的检出为我们探讨Ｇｒａｖｅｓ病发病机制提供了一条新思路。
TSH anti-idiotypic antibody (TSHAb2) was detected by rabbit anti-human TSHAb according to a new idiotype-anti-idiotypic immuno-network theory of the pathogenesis of autoimmune thyroid disease. To normal control, with its binding rate x +2 s upper limit of normal, greater than this value is positive. TSHAb2 was positive in 65% of 60 TRAb-positive patients and TSHAb2-positive in only 5% of 40 TRAb-negative patients. The difference between the two groups was significant (P <0.05). TRAb positive group, TRAb and TSHAb2 was positively correlated (r = 0.645, P <0.01). At the same time, the TRAb positive serum was adsorbed by the prepared TSH antibody and then tested for TRAb. The difference was significant (P <0.05) before and after adsorption. The detection of anti-TRAb antibody provides a new idea for us to explore the pathogenesis of Graves disease.