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测定９６例绝经前后无冠心病（ＣＨＤ）妇女的性激素、血脂和免疫蛋白水平，并对１８例绝经后妇女进行尼尔雌醇干预治疗。结果显示：绝经后妇女的Ｅ２，Ｅ２／Ｔ，ＨＤＬ及ＡｐｏＡＩ降低，Ｔ，ＴＧ，ＴＣ，ＬＤＬ－Ｃ，ＡｐｏＢ，Ｌｐ（ａ），ＩｇＧ及ＡｃＡＩｇＧ升高；Ｅ２与ＨＤＬ－Ｃ呈正相关，与ＴＣ，ＡｐｏＢ，Ｌｐ（ａ），ＬＤＬ－Ｃ，ＩｇＧ，ＡｃＡＩｇＧ呈负相关；Ｔ与ＬＤＬ－Ｃ，ＩｇＧ，ＡＣＡＩｇＧ呈正相关，与ＨＤＬ－Ｃ呈负相关；尼尔雌醇治疗后ＴＧ，ＴＣ，ＬＤＬ－Ｃ，ＩｇＧ，ＡＣＡＩｇＧ下降，ＨＤＬ－Ｃ上升。提示Ｅ２是ＣＨＤ保护性因子。绝经后Ｅ／Ｔ比例失调，使ＣＨＤ发病危险性增加，而尼尔雌醇是绝经后妇女防治ＣＨＤ有效的雌激素替代剂
The serum levels of sex hormones, lipids and immune proteins in 96 premenopausal and postmenopausal women without coronary heart disease (CHD) were measured. Niletriol intervention was given to 18 postmenopausal women. The results showed that the levels of E2, E2 / T, HDL and ApoAI, the levels of T, TG, TC, LDL-C, ApoB, Lp (a), IgG and AcAIgG in postmenopausal women were increased; E2 was positively correlated with HDL- TC, ApoB, Lp (a), LDL-C, IgG and AcAIgG were negatively correlated. T was positively correlated with LDL-C, IgG and ACAIgG and negatively correlated with HDL- LDL-C, IgG, ACAIgG decreased, HDL-C increased. Tip E2 is CHD protective factor. Postmenopausal E / T ratio disorders, the risk of CHD increased risk, while nilestriol is a postmenopausal women CHD effective estrogen replacement therapy