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近年制出PGE_1衍生物反式16、16-二甲基-Δ~2-前列腺素E_1甲基酯(ONO802)阴道栓剂,证明经阴道给予副作用较少,据报导有明显催流产作用。此次作者亦采用经阴道给予ONO802引产方法,将结果报告如下。对象为希望中断妊娠的19～34岁孕12～23周的孕妇25例,妊娠试验均为阳性,并经临床检查排除葡萄胎、死胎等异常妊娠。所用阴道栓剂内含反式16、16-二甲基-△~2-前列腺素E_1甲基酯1 mg,每3小时给药1次,1 mg/次,5次为一疗程。栓剂放于阴道后穹窿处。给药不足一个疗程者,子宫内容物如能完全排出则不再给药。各例在引产前皆未用其他药物或处置。引产效果根据WHO标准判定:给予ONO802 48小时内胎儿及其附属物完全排出者为完全流产;48小时内未完全排出,但以简
In recent years, PGE 1 trans-trans-16,16-dimethyl-Δ ~ 2-prostaglandin E-methyl ester (ONO802) vaginal suppository was produced, demonstrating less side effects of transvaginal administration, and it has been reported that there is a significant oxytocin-induced effect. The author also used transvaginal ONO802 induction of labor, the results reported below. Subjects who wish to interrupt the pregnancy of 19 to 34-year-old pregnant 12 to 23 weeks of pregnant women in 25 cases, pregnancy tests were positive, and through the clinical examination to exclude hydatidiform mole, stillbirth and other abnormal pregnancy. The vaginal suppository contained trans-16,16-dimethyl -? 2-prostaglandin E-1 methyl ester 1 mg, administered once every 3 hours, 1 mg / time, 5 times for a course of treatment. Suppositories placed in the vaginal fornix. Less than a course of treatment, uterine content can be completely discharged if no longer administered. Each case before induction of labor have not used other drugs or disposal. Induction of labor effects according to WHO criteria to determine: give ONO802 within 48 hours of complete removal of the fetus and its appendages were completely abortion; not completely discharged within 48 hours, but to Jane