本文应用绒毛细胞直接制备染色体的方法,对456名孕妇进行了产前诊断,成功437例,发现34例异常,异常率为7.78％。随访到282名孕妇,其中16名流产,流产率为5.67％。已出生的266名婴儿中,其性别、表型均与绒毛染色体检查诊断一致,未见畸形。提示此方法安全可靠、简便快速、实用有效,可作为产前早期诊断染色体病的首选方法。 In this study, 456 pregnant women were diagnosed with prenatal diagnosis using chromosomal direct preparation method of villus cells, 437 cases were successful and 34 cases were abnormal. The abnormal rate was 7.78%. Follow-up to 282 pregnant women, of whom 16 abortion, abortion rate of 5.67%. Of the 266 infants born, their gender and phenotype were consistent with the chromosomal diagnosis of villus, with no abnormalities. It is suggested that this method is safe, reliable, simple and rapid, practical and effective, which can be used as the first choice of prenatal diagnosis of chromosome disease.