内皮抑素(Endostatin)能特异性抑制血管内皮细胞的增生、迁移,并诱导其凋亡,从而抑制新生血管的形成;还可抑制斑块内膜血管生成从而抑制动脉粥样硬化斑块的生长。血管内皮生长因子(VEGF)可诱导内皮细胞增殖,促进新生血管形成。内皮抑素和VEGF作为血管形成的调节因子,可能与脑梗死的发生、发展及转归密切相关。 Endostatin can specifically inhibit the proliferation, migration and apoptosis of vascular endothelial cells, thus inhibiting the formation of neovascularization. It also inhibits plaque endothelium angiogenesis and thus inhibits the growth of atherosclerotic plaque . Vascular endothelial growth factor (VEGF) can induce endothelial cell proliferation and promote neovascularization. Endostatin and VEGF, as regulators of angiogenesis, may be closely related to the occurrence, development and prognosis of cerebral infarction.