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目的:评价化合物Y-IP5对小鼠吗啡镇痛、耐受及躯体依赖的影响。方法:采用55℃热板测痛模型分析Y-IP5对小鼠吗啡镇痛和耐受的影响;采用剂量递增法皮下注射吗啡5 d,建立小鼠吗啡依赖模型,评价Y-IP5对小鼠吗啡躯体依赖的影响。结果:在热板测痛模型中,Y-IP5(2.5,5,10 mg.kg-1)不能明显增强小鼠吗啡镇痛作用(P>0.05),Y-IP5(1.25,2.5,5 mg.kg-1)能明显抑制小鼠吗啡镇痛耐受的形成(P<0.05)。伴随吗啡给予Y-IP5(1.25,2.5,5 mg.kg-1)能剂量依赖性地抑制小鼠躯体依赖的形成(P<0.05);在纳洛酮催促前单次给予Y-IP5(1.25,2.5,5 mg.kg-1),不能显著抑制小鼠吗啡躯体依赖的表达(P>0.05)。结论:Y-IP5对吗啡耐受及躯体依赖的形成可能有一定的干预作用。
Objective: To evaluate the effects of compound Y-IP5 on morphine analgesia, tolerance and somatic dependence in mice. Methods: The effect of Y-IP5 on morphine analgesia and tolerance in mice was analyzed by hot plate test at 55 ℃. Morphine-dependent model of mice was established by subcutaneous injection of morphine for 5 days by dose escalation. Effects of morphine on body dependence. Results: Y-IP5 (2.5, 5, 10 mg.kg-1) did not significantly increase the morphine analgesia in mice (P> 0.05) .kg-1) could significantly inhibit the morphine analgesic tolerance in mice (P <0.05). Y-IP5 (1.25, 2.5, 5 mg.kg-1) with morphine inhibited the somatic-dependent formation of mice in a dose-dependent manner (P <0.05) , 2.5 and 5 mg.kg-1, respectively) did not significantly inhibit the body-dependent morphine-dependent expression in mice (P> 0.05). Conclusion: Y-IP5 may have some effects on the formation of morphine tolerance and somatic dependence.