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将雄性Wistar大鼠分:年轻组(2～3月龄)、成年组(12～13月龄)和老年组(21～22月龄),每年龄组24只;实验组、对照组各12只。实验组饲料加入中药8591共喂120天。结果发现,老年对照组大鼠睾丸明显萎缩,颜色较暗,重量为0.91±0.33克,实验组睾丸表面光滑,粉红色,饱潮,重量为1.86±0.21克;镜下见对照组曲细精管数和精子数显著少于给药组。老年实验组血浆睾酮水平降低,雌二醇水平升高,T/F降低,血清LH水平升高,下丘脑MAO水平增高等变化的程度,显著小于对照组。本研究的结果表明,中药8561明显地延缓了雄性大鼠下丘脑、垂体和性腺的老化过程。
Male Wistar rats were divided into two groups: young group (2 to 3 months old), adult group (12 to 13 months old) and old group (21 to 22 months old), 24 in each age group; each of the experimental group and control group 12 only. The experimental group feed was fed with Chinese medicine 8591 for 120 days. The results showed that the testis of the old control group was obviously shrunken with dark color and the weight was 0.91±0.33 g. In the experimental group, the testicular surface was smooth, pink, and full-thick, with a weight of 1.86±0.21 g; see the control group, seminiferous tubules under the microscope. The number of sperm and the number of sperm were significantly less than the administration group. The serum testosterone levels in the elderly experimental group decreased, estradiol levels increased, T/F decreased, serum LH levels increased, and the extent of changes in the hypothalamus MAO levels was significantly lower than in the control group. The results of this study indicate that traditional Chinese medicine 8561 significantly delayed the aging process in the hypothalamus, pituitary gland and gonads of male rats.